张珊珊,汪铭书,程安春,吴英

• 1:四川农业大学动物医学院禽病防治研究中心
• 2:四川农业大学预防兽医研究所
• 3:四川农业大学动物疫病与人类健康四川省重点实验室

摘要(Abstract)：

在单纯疱疹病毒1型（Herpes simplex virus 1,HSV-1）中，感染细胞蛋白8(Infected cell protein 8,ICP8)是由UL29基因编码的一种单链DNA结合蛋白（Single strand DNA-binding protein,SSBP），该蛋白在病毒复制中必不可缺，具有维持单链DNA的稳定性，并与其他病毒蛋白相互结合，促进病毒复制室的形成，介导晚期基因的表达。除此之外，ICP8还具有促进UL9编码的起源结合蛋白（Origin binding protein,OBP）和UL5/UL8/UL52蛋白的酶活性，与UL12蛋白共同介导链交换等功能。本文就上述目前国内外对HSV-1 ICP8的研究进展作一综述，以期为后续研究ICP8的作用机制提供参考。

关键词(KeyWords)： 单纯疱疹病毒1型(HSV-1);ICP8;单链结合蛋白(SSBP)

Abstract:

Keywords:

基金项目(Foundation): 四川省自然科学基金（项目号：22NSFSC3213）,题目：US1蛋白调控宿主RNAPII介导的鸭瘟病毒转录机制解析

作者(Author): 张珊珊,汪铭书,程安春,吴英

DOI: 10.13242/j.cnki.bingduxuebao.004351

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