侯贝;徐乐灵;王涛;

• 1:天津大学生命科学学院

摘要(Abstract)：

JAK/STAT信号通路是天然免疫过程中一条关键通路，参与了干扰素信号传递入细胞核的过程。研究表明，病毒通过逃避甚至利用JAK/STAT信号通路，对抗干扰素系统的抗病毒效果。在此过程中，调控干扰素受体蛋白、减少JAK和STAT蛋白的数量、阻碍STAT的磷酸化或核易位，又或是上调SOCS家族蛋白都是病毒常用的手段。本文重点介绍了病毒调控JAK/STAT信号通路的过程，为病毒致病机理的研究和抗病毒药物的设计提供了理论基础。

关键词(KeyWords)： JAK/STAT信号通路;SOCS;干扰素系统

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划“纳米科技”重点专项项目题目（项目号：2017YFA0205102）,题目：基于稀土发光纳米技术的病原体检测研究~~

作者(Authors): 侯贝;徐乐灵;王涛;

DOI: 10.13242/j.cnki.bingduxuebao.004187

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