吴玉湖,胡欣妍,杨宣叶,王进千,高明阳,马忠仁,周建华

• 1:西北民族大学
• 2:生物医学研究中心
• 3:生物工程与技术国家民委重点实验室
• 4:西北民族大学

摘要(Abstract)：

流感病毒是一种全球流行的呼吸道病原体，在其与宿主相互作用的过程中，病毒运用各种各样的方法逃避宿主抗病毒免疫系统的追击，而同时宿主也在不断武装自身免受病毒入侵，在这一系列过程中，泛素系统作为能够通过单个泛素或可逆性的泛素链与靶蛋白连接，进而使靶蛋白激活或失活的一种翻译后修饰机制。泛素化修饰在流感病毒复制过程中起到了至关重要的作用。因此，本篇综述结合近些年在此研究领域的研究成果，阐述了泛素化修饰参与病毒-宿主之间相互作用的机制，并为今后抗病毒药物的研发提供一个新的思路。

关键词(KeyWords)： 流感病毒;泛素系统;翻译后修饰;靶蛋白;病毒复制

Abstract:

Keywords:

基金项目(Foundation): 西北民族大学引进人才科研项目（项目号：Xbmuyjrc202225）,题目：BVDV NS系列非结构蛋白与核糖体内部核糖体进入位点元件互作的结构功能域研究~~

作者(Author): 吴玉湖,胡欣妍,杨宣叶,王进千,高明阳,马忠仁,周建华

DOI: 10.13242/j.cnki.bingduxuebao.004350

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