牛培华,许军,梁琦,张必科,赵翔,陈操,勾玉洁,冯晔囡,唐鹭,陈志肖,聂凯,李金松,王宏,吴寰宇,关旭华,许文波,王佶,孙巍,马学军

• 1:中国疾病预防控制中心病毒病预防控制所
• 2:国家卫生健康委医用病毒与病毒性疾病重点实验室
• 3:黑龙江省疾病预防控制中心
• 4:中国疾病预防控制中心

摘要(Abstract)：

本文报告了2021年10月至11月在中国黑龙江省暴发的具有8条传播链的SARS-CoV-2 Delta疫情中Delta亚型的感染和传播情况。我们收集了2021年10月至11月275例确诊病例和79份阳性食品包装样本。此次疫情涉及黑龙江省的两个城市：黑河市265例，哈尔滨市10例。通过全基因组测序（Whole Genome Sequencing,WGS）获得182例病例的有效全基因组序列和9份食品包装样品序列（包括3份高覆盖度的较完整基因组和6份片段化的序列）。基因组分析表明，本次疫情暴发是由VOC/Delta变异株（B.1.617.2进化分支）引起的，存在8条不同的传播链。所有182例感染者均可追溯到8个传播链中的指示病例。根据病毒基因组学和现场流行病学调查结果综合分析，在传播过程中形成的8条相对独立的传播链产生了至少三代病毒。在9份食品包装样品中共检测到50个单核苷酸多态性（Single nucleotide polymorphism,SNP），在8条传播链的指示病例中检测到89个SNP，两个SNP池共享41个SNP。这一潜在的基因组同源性提示，此次疫情可能是由进口的非冷链物品污染SARS-CoV-2 Delta变异株引起的。本次疫情中8条传播链病毒的基因组序列在近期国内流行数据库、境外输入病例数据库和全球数据库中未发现高度同源的序列，判定为新的境外输入病毒，提示本起疫情是一起新的境外输入疫情。

关键词(KeyWords)： 新型冠状病毒感染(COVID-19);新型冠状病毒(SARS-CoV-2);Delta;黑龙江;溯源分析

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 牛培华,许军,梁琦,张必科,赵翔,陈操,勾玉洁,冯晔囡,唐鹭,陈志肖,聂凯,李金松,王宏,吴寰宇,关旭华,许文波,王佶,孙巍,马学军

DOI: 10.13242/j.cnki.bingduxuebao.004342

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