王泽华;闵锐;周乐;张评浒;

• 1:扬州大学医学院转化医学研究院江苏省中西医结合老年病防治重点实验室
• 2:扬州市疾病预防控制中心

摘要(Abstract)：

流感主要是指由甲型流感病毒（Influenza A virus, IAV）感染引起的急性呼吸道疾病。构建差异化的感染动物模型模拟IAV的感染、发病及传播过程不仅有助于揭示流感病毒的传播机制与致病机理，而且对流感大流行的预警和防治有着重要意义。本文基于IAV跨种间传播的差异机制从不同动物模型呼吸道唾液酸受体亚型分布的表型差异及其对人流感病毒的易感性等多方面综述了流感病毒感染动物模型的优缺点及其最新研究进展，以期为IAV致病机制研究，疫苗药物的研发提供理论参考。

关键词(KeyWords)： 流感病毒;动物模型;唾液酸受体;感染机制;小鼠

Abstract:

Keywords:

基金项目(Foundation): 江苏省高等学校大学生创新创业训练计划项目（202111117111Y）,题目：季节性H3N2流感病毒药效评价模型的建立;; 扬州市科技局社会发展项目（YZ2020122）题目：新冠疫情下重症流感流行特征及生物标志物的研究~~

作者(Authors): 王泽华;闵锐;周乐;张评浒;

DOI: 10.13242/j.cnki.bingduxuebao.004249

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