杨娟;李岩;刘平;沈朝建;李吉达;毕玉海;韩岩岩;张毅;

• 1:遵义医科大学公共卫生学院
• 2:中国动物卫生与流行病学中心
• 3:中国科学院微生物研究所

摘要(Abstract)：

流感病毒是一种重要人畜共患病，严重危害人类健康和畜牧业发展。A型流感病毒（Influenza A Virus, IAV）在宿主细胞内的复制受到多种因素的影响和调节，近年来的研究证明，非编码RNA(ncRNA)，包括miRNA、LncRNA、CirRNA等，在流感病毒复制过程中起到重要的调控作用。ncRNA调控流感病毒复制有直接途径和间接途径两种，其中直接途径为直接作用于病毒的vRNA或mRNA，在转录或翻译水平影响病毒的复制。间接途径为作用于细胞内不同的信号通路，通过影响细胞因子合成、诱导宿主细胞凋亡、引起细胞自噬反应等途径，影响病毒的复制。通常情况下，由宿主编码的ncRNA能够抑制病毒的复制，而由病毒编码的ncRNA能够减弱宿主细胞的抗病毒反应，促进病毒复制。通过总结和梳理近年来关于ncRNA调控流感病毒复制的研究，我们发现ncRNA能够作为调控增强宿主细胞抗病毒免疫、下调病毒转录和翻译的工具，有望开发成为抗流感病毒靶向药物。后续的机制研究应不局限于某一种或几种ncRNA的作用，而应在ncRNA在宿主细胞内的分泌机制、调控的分子网络等方面进行深层次的探究。

关键词(KeyWords)： 非编码RNA;流感病毒;复制;宿主免疫;调控

Abstract:

Keywords:

基金项目(Foundation): 贵州省科学技术基金项目（遵科合基础-ZK[2021]一般082）,题目：流感病毒诱导外泌体miRNA对肺血管内皮细胞通透性的影响及分子调控机制研究;; 遵义市市校联合基金项目（遵市科合HZ字（2020）33号）,题目：流感病毒诱导外泌体调控肺血管内皮细胞通透性的分子机制研究;; 遵义医科大学学术新苗培养及创新探索专项项目（黔科合平台人才[2018]5772-070）,题目：流感病毒诱导外泌体miR-669e-5p靶向Robo4调控肺血管内皮细胞通透性的机制研究;; 遵义市科技支撑计划项目（遵市科合支撑GY(2021)66号）,题目：遵义市流感检测预警与宿主蛋白TMPRSS2调控流感病毒致病性的机制研究~~

作者(Authors): 杨娟;李岩;刘平;沈朝建;李吉达;毕玉海;韩岩岩;张毅;

DOI: 10.13242/j.cnki.bingduxuebao.004192

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