王慧慧;冯茜莉;蒲飞洋;汪梦竹;程燕;马晓霞;马忠仁;周建华;

• 1:西北民族大学生物医学研究中心
• 2:西北民族大学生命科学与工程学院
• 3:中国农业科学院兰州兽医研究所

摘要(Abstract)：

牛病毒性腹泻病毒（Bovine viral diarrhea virus, BVDV）基因组的高突变性和同源/异源重组性导致其成为一种较难防控的家畜病原体。目前普遍接受的两种基因型是BVDV-1和BVDV-2，其中基因1型含有21个亚型而基因2型含有4个亚型。在流行态势上，BVDV-1无论在遗传多样性还是分离毒株的数量上均高于BVDV-2。虽然BVDV-1和BVDV-2在基因组遗传特征上存在明显的遗传差异，但是其基因组内部特定区域在遗传进化上存在着密切关联。除了病毒基因组自身高变异的特性外，同源/异源RNA重组在BVDV遗传变异进程中也发挥着重要的作用。借助这些遗传进化的途径，BVDV在世界各地的流行传播可以用“随心所欲”来形容。BVDV的流行特征总体表现为基因1型的毒株为主要流行毒株，各基因亚型之间交替更迭并呈现遗传多样性。鉴于BVDV遗传进化的多变性和复杂性，紧密追踪主要流行基因亚型的更迭以及收集不同基因亚型的特征性遗传信息对于制定切实有效的BVDV防控措施具有实际意义。

关键词(KeyWords)： 牛病毒性腹泻病毒(BVDV);基因突变;RNA重组;遗传多样性;基因亚型

Abstract:

Keywords:

基金项目(Foundation): 西北民族大学引进人才科研项目（项目号：Xbmuyjrc202225）,题目：BVDV NS系列非结构蛋白与核糖体内部核糖体进入位点元件互作的结构功能域研究~~

作者(Authors): 王慧慧;冯茜莉;蒲飞洋;汪梦竹;程燕;马晓霞;马忠仁;周建华;

DOI: 10.13242/j.cnki.bingduxuebao.004218

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